Partial reconstitution of humoral immunity and fewer infections in patients with chronic lymphocytic leukemia treated with ibrutinib

Chronic lymphocytic leukemia (CLL) is characterized by immune dysregulation, often including hypogammaglobulinemia, which contributes to a high rate of infections and morbidity. Ibrutinib, a covalent inhibitor of Bruton tyrosine kinase (BTK), inhibits B-cell receptor signaling and is an effective, U...

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Bibliografske podrobnosti
izdano v:Blood
Main Authors: Sun, Clare, Tian, Xin, Lee, Yuh Shan, Gunti, Sreenivasulu, Lipsky, Andrew, Herman, Sarah E. M., Salem, Dalia, Stetler-Stevenson, Maryalice, Yuan, Constance, Kardava, Lela, Moir, Susan, Maric, Irina, Valdez, Janet, Soto, Susan, Marti, Gerald E., Farooqui, Mohammed Z., Notkins, Abner L., Wiestner, Adrian, Aue, Georg
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2015
Teme:
Lymphoid Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635117/
https://ncbi.nlm.nih.gov/pubmed/26337493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-04-639203
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