Adoptive transfer of activated marrow-infiltrating lymphocytes induces measurable antitumor immunity in the bone marrow in multiple myeloma

Successful adoptive T cell therapy (ACT) requires the ability to activate tumor-specific T cells with the ability to traffic to the tumor site and effectively kill their target as well as persist over time. We hypothesized that ACT using marrow-infiltrating lymphocytes (MILs) in multiple myeloma (MM...

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Publicado no:Sci Transl Med
Main Authors: Noonan, Kimberly A., Huff, Carol A., Davis, Janice, Lemas, M. Victor, Fiorino, Susan, Bitzan, Jeffrey, Ferguson, Anna, Emerling, Amy, Luznik, Leo, Matsui, William, Powell, Jonathan, Fuchs, Ephraim, Rosner, Gary L., Epstein, Caroline, Rudraraju, Lakshmi, Ambinder, Richard F., Jones, Richard J., Pardoll, Drew, Borrello, Ivan
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4634889/
https://ncbi.nlm.nih.gov/pubmed/25995224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa7014
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