Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case–control study

BACKGROUND: Antibodies to citrullinated proteins (ACPA) occur years before RA diagnosis. Porphyromonas gingivalis expresses its own peptidylarginine deiminase (PPAD), and is a proposed aetiological factor for the ACPA response. Smoking is a risk factor for both ACPA-positive RA and periodontitis. We...

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發表在:BMC Musculoskelet Disord
Main Authors: Fisher, Benjamin A., Cartwright, Alison J., Quirke, Anne-Marie, de Pablo, Paola, Romaguera, Dora, Panico, Salvatore, Mattiello, Amalia, Gavrila, Diana, Navarro, Carmen, Sacerdote, Carlotta, Vineis, Paolo, Tumino, Rosario, Lappin, David F., Apazidou, Danae, Culshaw, Shauna, Potempa, Jan, Michaud, Dominique S., Riboli, Elio, Venables, Patrick J.
格式: Artigo
語言:Inglês
出版: BioMed Central 2015
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4634856/
https://ncbi.nlm.nih.gov/pubmed/26537917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-015-0792-y
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