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Structural Analysis of Monomeric RNA-Dependent Polymerases: Evolutionary and Therapeutic Implications

The crystal structures of monomeric RNA-dependent RNA polymerases and reverse transcriptases of more than 20 different viruses are available in the Protein Data Bank. They all share the characteristic right-hand shape of DNA- and RNA polymerases formed by the fingers, palm and thumb subdomains, and,...

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Pubblicato in:PLoS One
Autori principali: Jácome, Rodrigo, Becerra, Arturo, Ponce de León, Samuel, Lazcano, Antonio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4634563/
https://ncbi.nlm.nih.gov/pubmed/26397100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139001
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