Evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases and the origin of RNA polymerases

BACKGROUND: The eukaryotic RNA-dependent RNA polymerase (RDRP) is involved in the amplification of regulatory microRNAs during post-transcriptional gene silencing. This enzyme is highly conserved in most eukaryotes but is missing in archaea and bacteria. No evolutionary relationship between RDRP and...

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Bibliographic Details
Main Authors: Iyer, Lakshminarayan M, Koonin, Eugene V, Aravind, L
Format: Artigo
Language:Inglês
Published: BioMed Central 2003
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC151600/
https://ncbi.nlm.nih.gov/pubmed/12553882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-3-1
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