Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study

BACKGROUND: Cognitive and motor task performance in premanifest Huntington's disease (HD) gene-carriers is often within normal ranges prior to clinical diagnosis, despite loss of brain volume in regions involved in these tasks. This indicates ongoing compensation, with the brain maintaining fun...

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Pubblicato in:EBioMedicine
Autori principali: Klöppel, Stefan, Gregory, Sarah, Scheller, Elisa, Minkova, Lora, Razi, Adeel, Durr, Alexandra, Roos, Raymund A.C., Leavitt, Blair R., Papoutsi, Marina, Landwehrmeyer, G. Bernhard, Reilmann, Ralf, Borowsky, Beth, Johnson, Hans, Mills, James A., Owen, Gail, Stout, Julie, Scahill, Rachael I., Long, Jeffrey D., Rees, Geraint, Tabrizi, Sarah J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4634199/
https://ncbi.nlm.nih.gov/pubmed/26629536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.08.002
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