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Reactivation of IgG-switched memory B cells by BCR-intrinsic signal amplification promotes IgG antibody production

Secondary antibody responses are marked by faster kinetics, improved antibody affinity and a switch from IgM to other immunoglobulin isotypes, most notably IgG, compared with primary responses. These changes protect from reinfection and represent the principle of most vaccination strategies. Yet, th...

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Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Lutz, Johannes, Dittmann, Kai, Bösl, Michael R, Winkler, Thomas H, Wienands, Jürgen, Engels, Niklas
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633962/
https://ncbi.nlm.nih.gov/pubmed/26815242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9575
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