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Reactivation of IgG-switched memory B cells by BCR-intrinsic signal amplification promotes IgG antibody production
Secondary antibody responses are marked by faster kinetics, improved antibody affinity and a switch from IgM to other immunoglobulin isotypes, most notably IgG, compared with primary responses. These changes protect from reinfection and represent the principle of most vaccination strategies. Yet, th...
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| Gepubliceerd in: | Nat Commun |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4633962/ https://ncbi.nlm.nih.gov/pubmed/26815242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9575 |
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