Substrate recognition and catalysis by LytB, a pneumococcal peptidoglycan hydrolase involved in virulence

Streptococcus pneumoniae is a major cause of life-threatening diseases worldwide. Here we provide an in-depth functional characterization of LytB, the peptidoglycan hydrolase responsible for physical separation of daughter cells. Identified herein as an N-acetylglucosaminidase, LytB is involved also...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Rico-Lastres, Palma, Díez-Martínez, Roberto, Iglesias-Bexiga, Manuel, Bustamante, Noemí, Aldridge, Christine, Hesek, Dusan, Lee, Mijoon, Mobashery, Shahriar, Gray, Joe, Vollmer, Waldemar, García, Pedro, Menéndez, Margarita
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633669/
https://ncbi.nlm.nih.gov/pubmed/26537571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16198
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