Improving chemotherapeutic efficiency in acute myeloid leukemia treatments by chemically synthesized peptide interfering with CXCR4/CXCL12 axis

Bone marrow stroma can protect acute myeloid leukemia (AML) cells against chemotherapeutic agents and provide anti-apoptosis and chemoresistance signals through secreting chemokine CXCL12 to activate its receptor CXCR4 on AML cells, resulting in minimal residual leukemia and relapse. Therefore disru...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Li, Xiaojin, Guo, Hua, Duan, Hongyang, Yang, Yanlian, Meng, Jie, Liu, Jian, Wang, Chen, Xu, Haiyan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633653/
https://ncbi.nlm.nih.gov/pubmed/26538086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16228
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