Mechanism of Action of Bortezomib and the New Proteasome Inhibitors on Myeloma Cells and the Bone Microenvironment: Impact on Myeloma-Induced Alterations of Bone Remodeling

Multiple myeloma (MM) is characterized by a high capacity to induce alterations in the bone remodeling process. The increase in osteoclastogenesis and the suppression of osteoblast formation are both involved in the pathophysiology of the bone lesions in MM. The proteasome inhibitor (PI) bortezomib...

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發表在:Biomed Res Int
Main Authors: Accardi, Fabrizio, Toscani, Denise, Bolzoni, Marina, Dalla Palma, Benedetta, Aversa, Franco, Giuliani, Nicola
格式: Artigo
語言:Inglês
出版: Hindawi Publishing Corporation 2015
主題:
Review Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633537/
https://ncbi.nlm.nih.gov/pubmed/26579531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/172458
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