Mechanism of Action of Bortezomib and the New Proteasome Inhibitors on Myeloma Cells and the Bone Microenvironment: Impact on Myeloma-Induced Alterations of Bone Remodeling

Multiple myeloma (MM) is characterized by a high capacity to induce alterations in the bone remodeling process. The increase in osteoclastogenesis and the suppression of osteoblast formation are both involved in the pathophysiology of the bone lesions in MM. The proteasome inhibitor (PI) bortezomib...

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Udgivet i:Biomed Res Int
Main Authors: Accardi, Fabrizio, Toscani, Denise, Bolzoni, Marina, Dalla Palma, Benedetta, Aversa, Franco, Giuliani, Nicola
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2015
Fag:
Review Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633537/
https://ncbi.nlm.nih.gov/pubmed/26579531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/172458
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