Mechanism of Action of Bortezomib and the New Proteasome Inhibitors on Myeloma Cells and the Bone Microenvironment: Impact on Myeloma-Induced Alterations of Bone Remodeling

Multiple myeloma (MM) is characterized by a high capacity to induce alterations in the bone remodeling process. The increase in osteoclastogenesis and the suppression of osteoblast formation are both involved in the pathophysiology of the bone lesions in MM. The proteasome inhibitor (PI) bortezomib...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Accardi, Fabrizio, Toscani, Denise, Bolzoni, Marina, Dalla Palma, Benedetta, Aversa, Franco, Giuliani, Nicola
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2015
Assuntos:
Review Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633537/
https://ncbi.nlm.nih.gov/pubmed/26579531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/172458
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