Effect of ABCG2/BCRP Expression on Efflux and Uptake of Gefitinib in NSCLC Cell Lines

BACKGROUND: BCRP/ABCG2 emerged as an important multidrug resistance protein, because it confers resistance to several classes of cancer chemotherapeutic agents and to a number of novel molecularly-targeted therapeutics such as tyrosine kinase inhibitors. Gefitinib is an orally active, selective EGFR...

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Vydáno v:PLoS One
Hlavní autoři: Galetti, Maricla, Petronini, Pier Giorgio, Fumarola, Claudia, Cretella, Daniele, La Monica, Silvia, Bonelli, Mara, Cavazzoni, Andrea, Saccani, Francesca, Caffarra, Cristina, Andreoli, Roberta, Mutti, Antonio, Tiseo, Marcello, Ardizzoni, Andrea, Alfieri, Roberta R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633241/
https://ncbi.nlm.nih.gov/pubmed/26536031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141795
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