p53 siRNA - a therapeutic tool with significant implication in the modulation of apoptosis and angiogenic pathways

BACKGROUND AND AIMS: siRNAs represent an encouraging novel alternative in cancer therapy as a result of targeting the mutated tumour suppressor genes or activated oncogenes. Targeting oncogenic signals, as the mutated p53 gene that gains oncogenic role, we observed inhibition of migration, a downreg...

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Bibliographic Details
Published in:Clujul Med
Main Authors: BRAICU, OVIDIU, PILECZKI, VALENTINA, BRAICU, CORNELIA, ACHIMAS-CADARIU, PATRICIU, IRIMIE, ALEXANDRU, BERINDAN-NEAGOE, IOANA
Format: Artigo
Language:Inglês
Published: Iuliu Hatieganu University of Medicine and Pharmacy 2015
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632892/
https://ncbi.nlm.nih.gov/pubmed/26609266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15386/cjmed-434
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