The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells

INTRODUCTION: The A673T mutation in the amyloid precursor protein (APP) protects against Alzheimer’s disease by reducing β-amyloid protein (Aβ) production. This mutation reduced the release of the soluble APP fragment (sAPPβ), which is processed by β-secretase, suggesting a concomitant decrease in t...

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Vydáno v:Acta Neuropathol Commun
Hlavní autoři: Kokawa, Asuka, Ishihara, Seiko, Fujiwara, Hitomi, Nobuhara, Mika, Iwata, Minori, Ihara, Yasuo, Funamoto, Satoru
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632685/
https://ncbi.nlm.nih.gov/pubmed/26531305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0247-6
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