Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes

DJ-1 mutation induces early-onset Parkinson's disease, and conversely over-expression of DJ-1 is associated with cancer in numerous tissues. A gene-trap screening library conducted in embryonic stem cells was utilized for generation of a DJ-1 mutant mouse. Real-time PCR and immunoblotting were...

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Detalhes bibliográficos
Publicado no:Toxicol Lett
Main Authors: Ashley, Amanda K., Hanneman, William H., Katoh, Takeshi, Moreno, Julie A., Pollack, Ashley, Tjalkens, Ronald B., Legare, Marie E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632527/
https://ncbi.nlm.nih.gov/pubmed/19063952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2008.11.008
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