Control of the dynamics and homeostasis of the Drosophila Hedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases

The conserved Hedgehog (HH) signals control animal development, adult stem cell maintenance and oncogenesis. In Drosophila, the HH co-receptor Patched (PTC) controls both HH gradient formation and signalling. PTC is post-translationally downregulated by HH, which promotes its endocytosis and destabi...

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Detaylı Bibliyografya
Yayımlandı:Open Biol
Asıl Yazarlar: Brigui, Amira, Hofmann, Line, Argüelles, Camilla, Sanial, Matthieu, Holmgren, Robert A., Plessis, Anne
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Royal Society 2015
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632511/
https://ncbi.nlm.nih.gov/pubmed/26446620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.150112
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