Advantages of a next generation sequencing targeted approach for the molecular diagnosis of retinoblastoma

BACKGROUND: Retinoblastoma (RB) is the most common malignant childhood tumor of the eye and results from inactivation of both alleles of the RB1 gene. Nowadays RB genetic diagnosis requires classical chromosome investigations, Multiplex Ligation-dependent Probe Amplification analysis (MLPA) and Sang...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Grotta, Simona, D’Elia, Gemma, Scavelli, Rossana, Genovese, Silvia, Surace, Cecilia, Sirleto, Pietro, Cozza, Raffaele, Romanzo, Antonino, De Ioris, Maria Antonietta, Valente, Paola, Tomaiuolo, Anna Cristina, Lepri, Francesca Romana, Franchin, Tiziana, Ciocca, Laura, Russo, Serena, Locatelli, Franco, Angioni, Adriano
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632486/
https://ncbi.nlm.nih.gov/pubmed/26530098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1854-0
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