A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties

INTRODUCTION: Activation of cyclooxygenase (COX)/prostaglandin and nuclear factor κB (NFκB) pathways can promote breast tumor initiation, growth, and progression to drug resistance and metastasis. Thus, anti-inflammatory drugs have been widely explored as chemopreventive and antineoplastic agents. A...

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Bibliographic Details
Published in:BMC Cancer
Main Authors: Kastrati, Irida, Litosh, Vladislav A., Zhao, Shuangping, Alvarez, Manuel, Thatcher, Gregory R. J., Frasor, Jonna
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632459/
https://ncbi.nlm.nih.gov/pubmed/26530254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1868-7
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