Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with marked chemoresistance and a 5-year survival rate of 7%. The integrated stress response (ISR) is a cytoprotective pathway initiated in response to exposure to various environmental stimuli. We used pancreatic cancer cells (PCCs) th...

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Dettagli Bibliografici
Pubblicato in:Cell Death Dis
Autori principali: Palam, L R, Gore, J, Craven, K E, Wilson, J L, Korc, M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632294/
https://ncbi.nlm.nih.gov/pubmed/26469962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.264
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