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The Nature, Extent, and Consequences of Genetic Variation in the opa Repeats of Notch in Drosophila
Polyglutamine (pQ) tracts are abundant in proteins co-interacting on DNA. The lengths of these pQ tracts can modulate their interaction strengths. However, pQ tracts >40 residues are pathologically prone to amyloidogenic self-assembly. Here, we assess the extent and consequences of variation in t...
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| Pubblicato in: | G3 (Bethesda) |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Genetics Society of America
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4632060/ https://ncbi.nlm.nih.gov/pubmed/26362765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.115.021659 |
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