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The Nature, Extent, and Consequences of Genetic Variation in the opa Repeats of Notch in Drosophila

Polyglutamine (pQ) tracts are abundant in proteins co-interacting on DNA. The lengths of these pQ tracts can modulate their interaction strengths. However, pQ tracts >40 residues are pathologically prone to amyloidogenic self-assembly. Here, we assess the extent and consequences of variation in t...

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Detalhes bibliográficos
Publicado no:G3 (Bethesda)
Main Authors: Rice, Clinton, Beekman, Danielle, Liu, Liping, Erives, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632060/
https://ncbi.nlm.nih.gov/pubmed/26362765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.115.021659
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