En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase.

Src homology region 2 (SH2) domains are present in many proteins involved in signal transduction. In nonreceptor protein tyrosine kinases the SH2 domain has been implicated in regulation of tyrosine kinase activity and in mediating interactions involved in downstream signaling. Different SH2 domains...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Muller, A J, Pendergast, A M, Parmar, K, Havlik, M H, Rosenberg, N, Witte, O N
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46319/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7682703/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.8.3457
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