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Genotypic Differences in Dengue Virus Neutralization Are Explained by a Single Amino Acid Mutation That Modulates Virus Breathing

Flaviviruses sample an ensemble of virion conformations resulting from the conformational flexibility of their structural proteins. To investigate how sequence variation among strains impacts virus breathing, we performed studies with the monoclonal antibody (MAb) E111, which binds an inaccessible d...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Dowd, Kimberly A., DeMaso, Christina R., Pierson, Theodore C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631804/
https://ncbi.nlm.nih.gov/pubmed/26530385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01559-15
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