EGFR kinase domain duplication (EGFR-KDD) is a novel oncogenic driver in lung cancer that is clinically responsive to afatinib

Oncogenic EGFR mutations are found in 10-35% of lung adenocarcinomas. Such mutations, which present most commonly as small in-frame deletions in exon 19 or point mutations in exon 21 (L858R), confer sensitivity to EGFR tyrosine kinase inhibitors (TKIs). In analyzing the tumor from a 33-year-old male...

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書誌詳細
出版年:Cancer Discov
主要な著者: Gallant, Jean-Nicolas, Sheehan, Jonathan H., Shaver, Timothy M., Bailey, Mark, Lipson, Doron, Chandramohan, Raghu, Brewer, Monica Red, York, Sally J., Kris, Mark G., Pietenpol, Jennifer A., Ladanyi, Marc, Miller, Vincent A., Ali, Siraj M., Meiler, Jens, Lovly, Christine M.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631701/
https://ncbi.nlm.nih.gov/pubmed/26286086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-0654
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