EGFR kinase domain duplication (EGFR-KDD) is a novel oncogenic driver in lung cancer that is clinically responsive to afatinib

Oncogenic EGFR mutations are found in 10-35% of lung adenocarcinomas. Such mutations, which present most commonly as small in-frame deletions in exon 19 or point mutations in exon 21 (L858R), confer sensitivity to EGFR tyrosine kinase inhibitors (TKIs). In analyzing the tumor from a 33-year-old male...

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Publicado en:Cancer Discov
Autores principales: Gallant, Jean-Nicolas, Sheehan, Jonathan H., Shaver, Timothy M., Bailey, Mark, Lipson, Doron, Chandramohan, Raghu, Brewer, Monica Red, York, Sally J., Kris, Mark G., Pietenpol, Jennifer A., Ladanyi, Marc, Miller, Vincent A., Ali, Siraj M., Meiler, Jens, Lovly, Christine M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631701/
https://ncbi.nlm.nih.gov/pubmed/26286086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-0654
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