Structural insights into the interaction of human IgG1 with FcγRI: no direct role of glycans in binding

The three-dimensional structure of a human IgG1 Fc fragment bound to wild-type human FcγRI is reported. The structure of the corresponding complex was solved at a resolution of 2.4 Å using molecular replacement; this is the highest resolution achieved for an unmutated FcγRI molecule. This study high...

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Pubblicato in:Acta Crystallogr D Biol Crystallogr
Autori principali: Oganesyan, Vaheh, Mazor, Yariv, Yang, Chunning, Cook, Kimberly E., Woods, Robert M., Ferguson, Andrew, Bowen, Michael A., Martin, Tom, Zhu, Jie, Wu, Herren, Dall’Acqua, William F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: International Union of Crystallography 2015
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631484/
https://ncbi.nlm.nih.gov/pubmed/26527150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004715018015
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