FireProt: Energy- and Evolution-Based Computational Design of Thermostable Multiple-Point Mutants

There is great interest in increasing proteins’ stability to enhance their utility as biocatalysts, therapeutics, diagnostics and nanomaterials. Directed evolution is a powerful, but experimentally strenuous approach. Computational methods offer attractive alternatives. However, due to the limited r...

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Bibliografiske detaljer
Udgivet i:PLoS Comput Biol
Main Authors: Bednar, David, Beerens, Koen, Sebestova, Eva, Bendl, Jaroslav, Khare, Sagar, Chaloupkova, Radka, Prokop, Zbynek, Brezovsky, Jan, Baker, David, Damborsky, Jiri
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631455/
https://ncbi.nlm.nih.gov/pubmed/26529612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004556
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