Depletion of UDP-Glucose and UDP-Galactose Using a Degron System Leads to Growth Cessation of Leishmania major

Interconversion of UDP-glucose (UDP-Glc) and UDP-galactose (UDP-Gal) by the UDP-Glc 4´-epimerase intimately connects the biosynthesis of these two nucleotide sugars. Their de novo biosynthesis involves transformation of glucose-6-phosphate into glucose-1-phosphate by the phosphoglucomutase and subse...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Damerow, Sebastian, Hoppe, Carolin, Bandini, Giulia, Zarnovican, Patricia, Buettner, Falk R., Lüder, Carsten G. K., Ferguson, Michael A. J., Routier, Françoise H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631452/
https://ncbi.nlm.nih.gov/pubmed/26529232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004205
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