Deletion of UDP-glucose pyrophosphorylase reveals a UDP-glucose independent UDP-galactose salvage pathway in Leishmania major

The nucleotide sugar UDP-galactose (UDP-Gal) is essential for the biosynthesis of several abundant glycoconjugates forming the surface glycocalyx of the protozoan parasite Leishmania major. Current data suggest that UDP-Gal could arise de novo by epimerization of UDP-glucose (UDP-Glc) or by a salvag...

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Detalhes bibliográficos
Main Authors: Lamerz, Anne-Christin, Damerow, Sebastian, Kleczka, Barbara, Wiese, Martin, van Zandbergen, Ger, Lamerz, Jens, Wenzel, Alexander, Hsu, Fong-Fu, Turk, John, Beverley, Stephen M., Routier, Françoise H.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900899/
https://ncbi.nlm.nih.gov/pubmed/20335578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cwq045
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