In vivo assessment of the metabolic activity of CYP2D6 diplotypes and alleles

AIMS: A prospectively enrolled patient cohort was used to assess whether the prediction of CYP2D6 phenotype activity from genotype data could be improved by reclassification of diplotypes or alleles. METHODS: Three hundred and fifty-five patients receiving tamoxifen 20 mg were genotyped for CYP2D6 a...

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Библиографические подробности
Опубликовано в: :Br J Clin Pharmacol
Главные авторы: Hertz, Daniel L, Snavely, Anna C, McLeod, Howard L, Walko, Christine M, Ibrahim, Joseph G, Anderson, Steven, Weck, Karen E, Magrinat, Gustav, Olajide, Oludamilola, Moore, Susan, Raab, Rachel, Carrizosa, Daniel R, Corso, Steven, Schwartz, Garry, Peppercorn, Jeffrey M, Evans, James P, Jones, David R, Desta, Zeruesenay, Flockhart, David A, Carey, Lisa A, Irvin, William J
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley & Sons, Ltd 2015
Предметы:
Pharmacogenetics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631184/
https://ncbi.nlm.nih.gov/pubmed/25907378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12665
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