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Targeting executioner procaspase-3 with the procaspase activating compound B-PAC-1 induces apoptosis in multiple myeloma cells
Multiple myeloma (MM) is a plasma cell neoplasm that has a low apoptotic index. We investigated a new class of small molecules that target the terminal apoptosis pathway, called procaspase activating compounds (PACs), in myeloma cells. PAC agents (PAC-1 and B-PAC-1) convert executioner procaspases (...
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| Publicado no: | Exp Hematol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4630139/ https://ncbi.nlm.nih.gov/pubmed/26257207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2015.07.005 |
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