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Mechanism of the nucleotidyl-transfer reaction in DNA polymerase revealed by time-resolved protein crystallography

Nucleotidyl-transfer reaction catalyzed by DNA polymerase is a fundamental enzymatic reaction for DNA synthesis. Until now, a number of structural and kinetic studies on DNA polymerases have proposed a two-metalion mechanism of the nucleotidyl-transfer reaction. However, the actual reaction process...

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Détails bibliographiques
Publié dans:Biophysics (Nagoya-shi)
Auteurs principaux: Nakamura, Teruya, Zhao, Ye, Yamagata, Yuriko, Hua, Yue-jin, Yang, Wei
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society of Japan (BSJ) 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4629682/
https://ncbi.nlm.nih.gov/pubmed/27493538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2142/biophysics.9.31
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