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Using ancestry matching to combine family-based and unrelated samples for genome-wide association studies()

We propose a method to analyze family-based samples together with unrelated cases and controls. The method builds on the idea of matched case–control analysis using conditional logistic regression (CLR). For each trio within the family, a case (the proband) and matched pseudo-controls are constructe...

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Publicat a:Stat Med
Autors principals: Crossett, Andrew, Kent, Brian P., Klei, Lambertus, Ringquist, Steven, Trucco, Massimo, Roeder, Kathryn, Devlin, Bernie
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4629477/
https://ncbi.nlm.nih.gov/pubmed/20862653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.4057
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