On the Use of General Control Samples for Genome-wide Association Studies: Genetic Matching Highlights Causal Variants

Resources being amassed for genome-wide association (GWA) studies include “control databases” genotyped with a large-scale SNP array. How to use these databases effectively is an open question. We develop a method to match, by genetic ancestry, controls to affected individuals (cases). The impact of...

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Autori principali: Luca, Diana, Ringquist, Steven, Klei, Lambertus, Lee, Ann B., Gieger, Christian, Wichmann, H.-Erich, Schreiber, Stefan, Krawczak, Michael, Lu, Ying, Styche, Alexis, Devlin, Bernie, Roeder, Kathryn, Trucco, Massimo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Human Genetics 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427172/
https://ncbi.nlm.nih.gov/pubmed/18252225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2007.11.003
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