Helical antimicrobial polypeptides with radial amphiphilicity

α-Helical antimicrobial peptides (AMPs) generally have facially amphiphilic structures that may lead to undesired peptide interactions with blood proteins and self-aggregation due to exposed hydrophobic surfaces. Here we report the design of a class of cationic, helical homo-polypeptide antimicrobia...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Xiong, Menghua, Lee, Michelle W., Mansbach, Rachael A., Song, Ziyuan, Bao, Yan, Peek, Richard M., Yao, Catherine, Chen, Lin-Feng, Ferguson, Andrew L., Wong, Gerard C. L., Cheng, Jianjun
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
Physical Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4629321/
https://ncbi.nlm.nih.gov/pubmed/26460016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507893112
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