Inhibition of acetylcholinesterase by two genistein derivatives: kinetic analysis, molecular docking and molecular dynamics simulation

In this study two genistein derivatives (G1 and G2) are reported as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and differences in the inhibition of AChE are described. Although they differ in structure by a single methyl group, the inhibitory effect of G1 (IC(50)=26...

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Detalhes bibliográficos
Publicado no:Acta Pharm Sin B
Main Authors: Fang, Jiansong, Wu, Ping, Yang, Ranyao, Gao, Li, Li, Chao, Wang, Dongmei, Wu, Song, Liu, Ai-Lin, Du, Guan-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4629110/
https://ncbi.nlm.nih.gov/pubmed/26579414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2014.10.002
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