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SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation
BACKGROUND: Amyotrophic Lateral Sclerosis is characterized by a focal onset of symptoms followed by a progressive spread of pathology that has been likened to transmission of infectious prions. Cell-to-cell transmission of SOD1 protein aggregates is dependent on fluid-phase endocytosis pathways, alt...
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Publicado no: | Mol Neurodegener |
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Main Authors: | , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
BioMed Central
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4628302/ https://ncbi.nlm.nih.gov/pubmed/26520394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0053-4 |
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