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In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383
PURPOSE: To assess accumulation and lysosomal sequestration of 9 drugs used in respiratory indications (plus imipramine as positive control) in the alveolar macrophage (AM) cell line NR8383. METHODS: For all drugs, uptake at 5 μM was investigated at 37 and 4°C to delineate active uptake and passive...
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| Publicado en: | Pharm Res |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Springer US
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4628094/ https://ncbi.nlm.nih.gov/pubmed/26224396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-015-1753-8 |
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