Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro

SCOPE: First- and second-generation antipsychotics (FGAs and SGAs, respectively), both inhibit cholesterol biosynthesis and impair the intracellular cholesterol trafficking, leading to lipid accumulation in the late endosome/lysosome compartment. In this study we examined if curcumin, a plant polyph...

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Опубликовано в: :PLoS One
Главные авторы: Canfrán-Duque, Alberto, Pastor, Oscar, Reina, Manuel, Lerma, Milagros, Cruz-Jentoft, Alfonso J., Lasunción, Miguel A., Busto, Rebeca
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627744/
https://ncbi.nlm.nih.gov/pubmed/26517556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141829
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