Measurement of Free Versus Total Therapeutic Monoclonal Antibody in Pharmacokinetic Assessment is Modulated by Affinity, Incubation Time, and Bioanalytical Platform

Decisions about efficacy and safety of therapeutic proteins (TP) designed to target soluble ligands are made in part by their ex vivo quantification. Ligand binding assays (LBAs) are critical tools in measuring serum TP levels in pharmacokinetic, toxicokinetic, and pharmacodynamic studies. This stud...

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Veröffentlicht in:AAPS J
Hauptverfasser: Talbot, Jeffrey J., Calamba, Dominador, Pai, Melody, Ma, Mark, Thway, Theingi M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer US 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627453/
https://ncbi.nlm.nih.gov/pubmed/26265093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9807-8
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