Network analysis of gene essentiality in functional genomics experiments

Many genomic techniques have been developed to study gene essentiality genome-wide, such as CRISPR and shRNA screens. Our analyses of public CRISPR screens suggest protein interaction networks, when integrated with gene expression or histone marks, are highly predictive of gene essentiality. Meanwhi...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Jiang, Peng, Wang, Hongfang, Li, Wei, Zang, Chongzhi, Li, Bo, Wong, Yinling J., Meyer, Cliff, Liu, Jun S., Aster, Jon C., Liu, X. Shirley
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627418/
https://ncbi.nlm.nih.gov/pubmed/26518695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0808-9
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