Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA.

Many cytotoxic anticancer drugs act at topoisomerase II (topo II) by stabilizing cleavable complexes with DNA formed by this enzyme. Several cell lines, selected for resistance to topo II-interactive drugs, show decreased expression or activity of topo II, suggesting that such a decrease may be resp...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Gudkov, A V, Zelnick, C R, Kazarov, A R, Thimmapaya, R, Suttle, D P, Beck, W T, Roninson, I B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46273/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8386368/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.8.3231
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