Deletion of Smad3 improves cardiac allograft rejection in mice

T cells play a critical role in acute allograft rejection. TGF-β/Smad3 signaling is a key pathway in regulating T cell development. We report here that Smad3 is a key transcriptional factor of TGF-β signaling that differentially regulates T cell immune responses in a mouse model of cardiac allograft...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wang, Ying-ying, Jiang, Hong, Wang, Yu-cheng, Huang, Xiao-ru, Pan, Jun, Yang, Chen, Shou, Zhang-fei, Xiang, Shi-long, Chen, Da-jin, Lan, Hui-yao, Chen, Jiang-hua
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
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Research Paper: Pathology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627288/
https://ncbi.nlm.nih.gov/pubmed/26219259
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