High-throughput simultaneous screen and counterscreen identifies homoharringtonine as synthetic lethal with von Hippel-Lindau loss in renal cell carcinoma

Renal cell carcinoma (RCC) accounts for 85% of primary renal neoplasms, and is rarely curable when metastatic. Approximately 70% of RCCs are clear-cell type (ccRCC), and in >80% the von Hippel-Lindau (VHL) gene is mutated or silenced. We developed a novel, high-content, screening strategy for the...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wolff, Nicholas C., Pavía-Jiménez, Andrea, Tcheuyap, Vanina T., Alexander, Shane, Vishwanath, Mridula, Christie, Alana, Xie, Xian-Jin, Williams, Noelle S., Kapur, Payal, Posner, Bruce, McKay, Renée M., Brugarolas, James
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627284/
https://ncbi.nlm.nih.gov/pubmed/26219258
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