Strain-Dependent Anterior Segment Dysgenesis and Progression to Glaucoma in Col4a1 Mutant Mice

PURPOSE: Mutations in the gene encoding collagen type IV alpha 1 (COL4A1) cause multisystem disorders including anterior segment dysgenesis (ASD) and optic nerve hypoplasia. The penetrance and severity of individual phenotypes depends on genetic context. Here, we tested the effects of a Col4a1 mutat...

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Publicado en:Invest Ophthalmol Vis Sci
Autores principales: Mao, Mao, Smith, Richard S., Alavi, Marcel V., Marchant, Jeffrey K., Cosma, Mihai, Libby, Richard T., John, Simon W. M., Gould, Douglas B.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Association for Research in Vision and Ophthalmology 2015
Materias:
Glaucoma
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627250/
https://ncbi.nlm.nih.gov/pubmed/26567795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-17527
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