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Strain-Dependent Anterior Segment Dysgenesis and Progression to Glaucoma in Col4a1 Mutant Mice
PURPOSE: Mutations in the gene encoding collagen type IV alpha 1 (COL4A1) cause multisystem disorders including anterior segment dysgenesis (ASD) and optic nerve hypoplasia. The penetrance and severity of individual phenotypes depends on genetic context. Here, we tested the effects of a Col4a1 mutat...
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Publicado no: | Invest Ophthalmol Vis Sci |
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Main Authors: | , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
The Association for Research in Vision and Ophthalmology
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4627250/ https://ncbi.nlm.nih.gov/pubmed/26567795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-17527 |
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