Loss of ATRX, associated with DNA methylation pattern of chromosome end, impacted biological behaviors of astrocytic tumors

Loss of ATRX leads to epigenetic alterations, including abnormal levels of DNA methylation at repetitive elements such as telomeres in murine cells. We conducted an extensive DNA methylation and mRNA expression profile study on a cohort of 82 patients with astrocytic tumors to study whether ATRX exp...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Cai, Jinquan, Chen, Jing, Zhang, Wei, Yang, Pei, Zhang, Chuanbao, Li, Mingyang, Yao, Kun, Wang, Hongjun, Li, Qingbin, Jiang, Chuanlu, Jiang, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627238/
https://ncbi.nlm.nih.gov/pubmed/25971279
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