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Selective Phosphodiesterase Inhibitors for Psoriasis: Focus on Apremilast
Phosphodiesterase (PDE) 4 participates in regulating the inflammatory response by degrading cyclic adenosine 3′,5′-monophosphate (cAMP), a key second messenger. Inhibition of PDE4 increases the intracellular cAMP level, which in turn results in a reduction in inflammatory mediators and an increase i...
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| Publicado no: | BioDrugs |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4626529/ https://ncbi.nlm.nih.gov/pubmed/26481941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40259-015-0144-3 |
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