The Genomic Landscape of Juvenile Myelomonocytic Leukemia

Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm (MPN) of childhood with a poor prognosis. Mutations in NF1, NRAS, KRAS, PTPN11 and CBL occur in 85% of patients, yet there are currently no risk stratification algorithms capable of predicting which patients will be refractory...

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發表在:Nat Genet
Main Authors: Stieglitz, Elliot, Taylor-Weiner, Amaro N., Chang, Tiffany Y., Gelston, Laura C., Wang, Yong-Dong, Mazor, Tali, Esquivel, Emilio, Yu, Ariel, Seepo, Sara, Olsen, Scott, Rosenberg, Mara, Archambeault, Sophie L., Abusin, Ghada, Beckman, Kyle, Brown, Patrick A., Briones, Michael, Carcamo, Benjamin, Cooper, Todd, Dahl, Gary V., Emanuel, Peter D., Fluchel, Mark N., Goyal, Rakesh K., Hayashi, Robert J., Hitzler, Johann, Hugge, Christopher, Liu, Y. Lucy, Messinger, Yoav H., Mahoney, Donald H., Monteleone, Philip, Nemecek, Eneida R., Roehrs, Philip A., Schore, Reuven J., Stine, Kimo C., Takemoto, Clifford M., Toretsky, Jeffrey A., Costello, Joseph F., Olshen, Adam B., Stewart, Chip, Li, Yongjin, Ma, Jing, Gerbing, Robert B., Alonzo, Todd A., Getz, Gad, Gruber, Tanja, Golub, Todd, Stegmaier, Kimberly, Loh, Mignon L.
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4626387/
https://ncbi.nlm.nih.gov/pubmed/26457647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3400
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