The Genomic Landscape of Juvenile Myelomonocytic Leukemia

Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm (MPN) of childhood with a poor prognosis. Mutations in NF1, NRAS, KRAS, PTPN11 and CBL occur in 85% of patients, yet there are currently no risk stratification algorithms capable of predicting which patients will be refractory...

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Pubblicato in:Nat Genet
Autori principali: Stieglitz, Elliot, Taylor-Weiner, Amaro N., Chang, Tiffany Y., Gelston, Laura C., Wang, Yong-Dong, Mazor, Tali, Esquivel, Emilio, Yu, Ariel, Seepo, Sara, Olsen, Scott, Rosenberg, Mara, Archambeault, Sophie L., Abusin, Ghada, Beckman, Kyle, Brown, Patrick A., Briones, Michael, Carcamo, Benjamin, Cooper, Todd, Dahl, Gary V., Emanuel, Peter D., Fluchel, Mark N., Goyal, Rakesh K., Hayashi, Robert J., Hitzler, Johann, Hugge, Christopher, Liu, Y. Lucy, Messinger, Yoav H., Mahoney, Donald H., Monteleone, Philip, Nemecek, Eneida R., Roehrs, Philip A., Schore, Reuven J., Stine, Kimo C., Takemoto, Clifford M., Toretsky, Jeffrey A., Costello, Joseph F., Olshen, Adam B., Stewart, Chip, Li, Yongjin, Ma, Jing, Gerbing, Robert B., Alonzo, Todd A., Getz, Gad, Gruber, Tanja, Golub, Todd, Stegmaier, Kimberly, Loh, Mignon L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4626387/
https://ncbi.nlm.nih.gov/pubmed/26457647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3400
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