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Designing a Study to Evaluate the Benefit of a Biomarker for Selecting Patient Treatment

Biomarkers that predict the efficacy of treatment can potentially improve clinical outcomes and decrease medical costs by allowing treatment to be provided only to those most likely to benefit. We consider the design of a randomized clinical trial in which one objective is to evaluate a treatment se...

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Pubblicato in:Stat Med
Autori principali: Janes, Holly, Brown, Marshall D, Pepe, Margaret S
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4626364/
https://ncbi.nlm.nih.gov/pubmed/26112650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6564
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